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Rifaximin is a semisynthetic antibiotic derived from rifamycin. Unlike many other oral antibiotics, it is minimally absorbed through the gastrointestinal tract into the bloodstream. Rifaximin works by inhibiting bacterial RNA synthesis through its action on the beta subunit of DNA-dependent RNA polymerase. It demonstrates broad-spectrum bactericidal activity, effective against a variety of Gram-positive and Gram-negative, as well as aerobic and anaerobic bacteria, similar to rifamycin.
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✅ Description:
Hepaximin 200 is an antibiotic used to treat hepatic encephalopathy, a condition caused by the liver's inability to remove toxins from the blood, which can lead to brain damage. Symptoms of this condition include agitation, confusion, muscle issues, difficulty speaking, and, in severe cases, coma. Additionally, Hepaximin 200 is used for treating infectious diarrhea and irritable bowel syndrome with diarrhea (IBS-D) in both adults and children.
This medicine can be taken alone or in combination with other medications. It can be taken with or without food, but it is best to take it at the same time each day to maximize its benefits. Always follow your doctor's prescribed dose and treatment duration. Do not stop the medication prematurely, as this may cause the infection to return and become harder to treat.
Common side effects include nausea, vomiting, dizziness, and headache, which are typically mild and resolve as your body adjusts to the medicine. Consult your doctor if these symptoms persist or worsen. It’s normal for this medicine to cause a reddish discoloration of urine, which is harmless.
Before starting Hepaximin 200, inform your doctor if you are pregnant, breastfeeding, or have any liver, kidney, or heart conditions, or if you are allergic to any medications.
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✔️ Uses of Hepaximin 200
- Traveler's Diarrhea
- Hepatic encephalopathy
- Irritable bowel syndrome associated with diarrhea
✔️ How does Hepaximin 200 work?
This medicine works by interfering with some vital processes in the bacterial cell and stopping the growth and multiplication of the microorganism
✔️ Hepaximin 200: Common side effects include:
- Flatulence, abdominal pain, nausea, vomiting, constipation, diarrhea, headache, and rectal tenesmus.
- Rare but serious reactions may include anaphylaxis, angioedema, and exfoliative dermatitis.
There is no specific treatment for Rifaximin overdose. In case of an overdose, discontinue the medication and provide symptomatic and supportive care as needed.
✔️ Quick Suggestions:
- Take Hepaximin 200 as instructed by the doctor.
- It is advised to take this medicine for the entire prescribed duration even when the symptoms have resolved.
- Hepaximin 200 can be taken with or without food.
- An adequate amount of water should be consumed while and after taking this medicine.
✔️ Hepaximin is indicated for:
- Treatment of traveler’s diarrhea caused by non-invasive strains of E. coli
- Reducing the risk of overt hepatic encephalopathy
- Managing bacterial overgrowth in irritable bowel syndrome
Always use this medication as per the advice of a registered physician.
✔️ Dosage & Administration of Hepaximin 200
- Traveler’s Diarrhea: For individuals aged 12 years and above, take 200 mg three times daily for 3 days.
- Hepatic Encephalopathy: For adults aged 18 years and older, take 550 mg twice daily.
- Bacterial Overgrowth in IBS:
- 400 mg three times daily for 10 days, or
- 550 mg three times daily for 14 days.
This medication can be taken with or without food.
- Renal Impairment: The effects of Rifaximin in patients with kidney dysfunction have not been studied.
- Hepatic Impairment: Patients with liver dysfunction may have significantly increased systemic exposure to Rifaximin compared to healthy individuals.
Always use this medication as per the advice of a registered physician.
✔️ Drug Interactions
In vitro studies suggest that Hepaximin may induce CYP3A4 enzyme activity. However, at the recommended dosage, it is not expected to induce CYP3A4 in individuals with normal liver function.
✔️ Hepaximin should not be used in individuals with:
- A known hypersensitivity to Rifaximin, rifamycin-based antimicrobials, or any of its components.
✔️ Pregnancy & Lactation
- Pregnancy: Classified as Category C. The safety of Hepaximin in pregnant women has not been established.
- Lactation: It is unknown if Rifaximin is excreted in human breast milk.
✔️ Precautions & Warnings
- Hepaximin is ineffective for diarrhea accompanied by fever or blood in stools.
- Discontinue use if diarrhea worsens or persists beyond 24-48 hours and consider an alternative antibiotic.
- Cases of pseudomembranous colitis have been reported with nearly all antibacterial agents, including Rifaximin. This condition may range from mild to life-threatening and should be considered if diarrhea occurs during or after treatment.
✔️ Storage:
Store below 30°C, away from light and moisture. Keep out of the reach of children.
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